Immethridine (dihydrobromide)

Immethridine (dihydrobromide) is a potent and highly selective histamine H (3) receptor agonist with pKi and pEC50 value of 9.07 and 9.74, respectively. Immethridine can be used for the research of myocardial ischemia, inflammatory, and gastric acid related diseases research[1].

Product Specifications

CAS Number

[699020-93-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/immethridine-dihydrobromide.html

Solubility

10 mM in DMSO

Smiles

[H]Br.[H]Br.C1(CC2=CN=CN2)=CC=NC=C1

Molecular Formula

C9H11Br2N3

Molecular Weight

321.01

Precautions

P261-P280-P302+P352

References & Citations

[1]Shi Y, et al. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells. Oncotarget. 2017 Aug 24;8 (43) :75038-75049.|[2]Kitbunnadaj R, et al. Identification of 4- (1H-imidazol-4 (5) -ylmethyl) pyridine (immethridine) as a novel, potent, and highly selective histamine H (3) receptor agonist. J Med Chem. 2004 May 6;47 (10) :2414-7.