Dyclonine (hydrochloride)
Product Specifications
UNSPSC Description
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].
Target Antigen
Aldehyde Dehydrogenase (ALDH); Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dyclonine-hydrochloride.html
Purity
99.86
Solubility
DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl
Molecular Weight
325.87
References & Citations
[1]Okazaki S, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73):33832-33843. |[2]FLORESTANO HJ, et al. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45(5):320-5. |[3]Khanna M, et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286(50):43486-94.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0364A/Dyclonine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0364A/Dyclonine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
536-43-6
Available Sizes
Curated Selection
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