Dyclonine (hydrochloride)

Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].

Product Specifications

CAS Number

[536-43-6]

Product Name Alternative

Dyclocaine hydrochloride

UNSPSC

12352005

Hazard Statement

H301, H315, H318, H335

Target

Aldehyde Dehydrogenase (ALDH) ; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dyclonine-hydrochloride.html

Purity

99.30

Solubility

DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl

Molecular Formula

C18H28ClNO2

Molecular Weight

325.87

Precautions

H301, H315, H318, H335

References & Citations

[1]Okazaki S, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9 (73) :33832-33843. |[2]FLORESTANO HJ, et al. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45 (5) :320-5. |[3]Khanna M, et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286 (50) :43486-94.