SRI 37892

SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC50=2μM) . SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents [1].

Product Specifications

CAS Number

[1030769-75-5]

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sri-37892.html

Purity

98.92

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NC(C2=CC3=C(NC(CC3)=O)C=C2)=CS1)C4=CC=C(N5C6=CC=CC=C6N=C5)C=C4

Molecular Formula

C26H19N5O2S

Molecular Weight

465.53

References & Citations

[1]Zhang W, et al. Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain. Oncotarget. 2017 Sep 6;8 (53) :91459-91470.