TIM-063

TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively[1].

Product Specifications

CAS Number

[2493978-38-2]

UNSPSC

12352005

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tim-063.html

Purity

96.63

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC=CC3=C([N+]([O-])=O)C(O)=CC(C4=NC5=C(N14)C=CC=C5)=C32

Molecular Formula

C18H9N3O4

Molecular Weight

331.28

References & Citations

[1]Satomi Ohtsuka, et al. Development and Characterization of Novel Molecular Probes for Ca2+/Calmodulin-Dependent Protein Kinase Kinase, Derived from STO-609. Biochemistry. 2020 May 5;59 (17) :1701-1710.