Bepridil (hydrochloride hydrate)

Bepridil hydrochloride hydrate ((±) -Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].

Product Specifications

CAS Number

[74764-40-2]

Product Name Alternative

(±) -Bepridil (hydrochloride hydrate) ; Org 5730 (hydrochloride hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bepridil-hydrochloride-hydrate.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H]

Molecular Formula

C24H37ClN2O2

Molecular Weight

421.02

Precautions

H302, H315, H319

References & Citations

[1]A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69 (11) :11D-16D.|[2]D R Harder, et al. Bepridil Blockade of Ca2+-dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery. J Cardiovasc Pharmacol. Jul-Aug 1981;3 (4) :906-14.|[3]Yasuhide Watanabe. Cardiac Na +/Ca 2+ Exchange Stimulators Among Cardioprotective Drugs. J Physiol Sci. 2019 Nov;69 (6) :837-849.|[4]A Yatani, et al. Bepridil Block of Cardiac Calcium and Sodium Channels. J Pharmacol Exp Ther. 1986 Apr;237 (1) :9-17.|[5]J C Wang, et al. Bepridil Differentially Inhibits Two Delayed Rectifier K (+) Currents, I (Kr) and I (Ks), in Guinea-Pig Ventricular Myocytes. Br J Pharmacol. 1999 Dec;128 (8) :1733-8.|[6]L Z Benet, et al. Pharmacokinetics and Metabolism of Bepridil. Am J Cardiol. 1985 Mar 15;55 (7) :8C-13C.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Calcium Channel

Citation 01

Università Vita-Salute San Raffaele. 2022 Apr 08. 34.|Acta Pharmacol Sin. 2025 May;46 (5) :1190-1204.|Biochem Biophys Res Commun. 2025 Oct 30:786:152756.|bioRxiv. 2025 Nov 21:2025.11.20.689520.|Eur J Pharm Sci. 2021 Sep 1:164:105889.|Eur J Pharm Sci. 2023 Aug 1:187:106475.|Research Square Preprint. 2024 Feb 9.|Virology. 2020 Jan 2;539:38-48.