PFI-6-COOH
PFI-6-COOH (Compound 18) is an eleven-nineteen leukemia (ENL) ligand, and can be used for synthesis of MS41 (HY-169093), an ENL PROTAC degrader[1].
Product Specifications
CAS Number
[2768514-05-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pfi-6-cooh.html
Smiles
O=C(O)C1=CC=C2CC[C@H](C2=C1)NC(C3=NOC(C4=CC(O)=C(C=C4)C(N(C)C)=O)=C3)=O
Molecular Formula
C23H21N3O6
Molecular Weight
435.43
References & Citations
[1]Xue Z, et al. A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci Adv. 2024 Aug 30;10 (35) :eado1432.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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