JMV 449

This compound is a potent and metabolically stable neurotensin receptor agonist, exhibiting high affinity (IC50 = 0.15 nM) and functional activity (EC50 = 1.9 nM) . Upon central administration in mice, it induces sustained hypothermia, analgesia, and neuroprotection, making it a valuable research tool for studying neurotensin signaling in pain, thermoregulation, and neurobiology.