Phrixotoxin 3 TFA

Phrixotoxin 3 TFA is a gating-modifier toxin that potently inhibits voltage-gated sodium channels, with highest affinity for NaV1.2 (IC50=0.6 nM) . It induces a depolarizing shift in gating and blocks inward current, making it a valuable tool for studying channel function and pharmacology in neuronal and cardiac electrophysiology research.