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IWP-2

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ[1][2].

Product Specifications

CAS Number

[686770-61-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Casein Kinase; Porcupine; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IWP-2.html

Purity

99.93

Solubility

DMF : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Molecular Formula

C22H18N4O2S3

Molecular Weight

466.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5 (2) :100-7.|[2]Maiti G, et al. The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16600-5.|[3]García-Reyes B, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61 (9) :4087-4102.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CK1

Citation 01

ACS Comb Sci. 2019 Dec 9;21 (12) :805-816.|Adv Mater. 2021 Dec;33 (49) :e2104829.|Autoimmunity. 2023 Dec;56 (1) :2182741.|Biocell. 2025 Feb 28.|Biochem Pharmacol. 2019 Nov;169:113608.|Bioengineering (Basel) . 2023 Jun 9;10 (6) :702.|bioRxiv. 2024 Mar 13.|Cell Rep Methods. 2024 May 8:100777.|Clin Sci. 2023 Jan 13;137 (1) :109-127.|Dev Cell. 2020 Dec 21;55 (6) :679-694.e11.|eNeuro. 2025 Jan 9:ENEURO.0347-24.2024.|Exp Cell Res. 2022 Nov 11;422 (1) :113416.|Exp Ther Med. 2020 Mar;19 (3) :1701-1710.|J Appl Polym Sci. 2024 Sep 25.|J Cell Physiol. 2020 Jul;235 (7-8) :5811-5822.|J Inflamm Res. 2024 Nov 19:17:8945-8964.|Microb Pathog. 2024 Sep 21:106960.|Neoplasia. 2024 Dec 30:60:101096.|Patent. US20180263995A1.|PLoS One. 2024 Jan 5;19 (1) :e0287206.|SSRN. 2024 Mar 26.|Stem Cell Res Ther. 2024 Oct 8;15 (1) :350.|Stem Cells Transl Med. 2021 May;10 (5) :743-755.|Toxicon. 2026 Jan:269:108660.|Nat Protoc. 2024 Jul;19 (7) :1911-1939.

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