IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ[1][2].
Product Specifications
CAS Number
686770-61-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase; Porcupine; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IWP-2.html
Purity
99.93
Solubility
DMF : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Molecular Formula
C22H18N4O2S3
Molecular Weight
466.60
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Citation 01
Available Sizes
Frequently Asked Questions
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