(Glu2) -TRH

(Glu2) -TRH is a metabolically stable TRH analogue that functions as a negative allosteric modulator, inhibiting TRH-induced acetylcholine release in the hippocampus. This compound demonstrates neuroprotective, antidepressant, and anticonvulsant activities in central nervous system research, making it a valuable tool for in vivo and in vitro studies of cholinergic modulation and neuropsychiatric disorders.