JUN-1111

JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2].

Product Specifications

CAS Number

[874351-38-9]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jun-1111.html

Purity

98.57

Solubility

DMSO : 100 mg/mL (ultrasonic; heat to 80°C)

Smiles

O=C(C=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O

Molecular Formula

C15H17N3O3

Molecular Weight

287.31

References & Citations

[1]Brisson M, et al. Redox regulation of Cdc25B by cell-active quinolinediones. Mol Pharmacol. 2005 Dec;68 (6) :1810-20. |[2]Vogt A, et al. A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther. 2008 Feb;7 (2) :330-40.