K 41498 TFA

K 41498 is a potent and selective peptide antagonist of human CRF2α and CRF2β receptors (Ki ~0.6 nM) with >600-fold selectivity over CRF1. It reverses urocortin-induced hypotension in vivo and modulates inflammatory pain thresholds in rat models, supporting research in stress-related cardiovascular and nociceptive pathways.