Klotho-derived Peptide 1 (56-87) (human) TFA

KP1 (Klotho-derived peptide 1 (56-87) ) is a human Klotho fragment that inhibits TGF-β signaling by binding to TGFBR1/TGFBR2. It reduces fibrotic markers like fibronectin and α-SMA in vitro and ameliorates kidney injury and fibrosis in murine UUO and ischemia-reperfusion models, demonstrating therapeutic research potential for renal fibrosis.