Xanthine oxidase-IN-14

Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM[1].

Product Specifications

CAS Number

[80025-67-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xanthine-oxidase-in-14.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N)N(C2=CC=C(C(F)(F)F)C=C2)N=C1

Molecular Formula

C11H7F3N4

Molecular Weight

252.20

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Gupta S, et al., Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors. Eur J Med Chem. 2008 Apr;43 (4) :771-80.