VSTx-3

VSTx-3 is a dual-function small molecule inhibitor, blocking potassium voltage-gated channels and potently inhibiting TTX-sensitive sodium channels, particularly NaV1.8. It demonstrates nanomolar potency against hNaV1.3, hNaV1.7, and hNaV1.8 subtypes. This profile makes it a valuable research tool for studying pain pathways and neuronal excitability in vitro.