5-Iodouridine

5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia[1][2][3].

Product Specifications

CAS Number

[1024-99-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/5-iodouridine.html

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C9H11IN2O6

Molecular Weight

370.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Bresnick E, et al. Inhibition of dihydroorotase by purines and pyrimidines. Biochimica et Biophysica Acta (BBA) -Specialized Section on Enzymological Subjects, 1964, 81 (1) : 150-157. |[2]Kuroda Y, et al. Radiosensitization of cultured mammalian cells by 5-iodouridine. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Mar;27 (3) :247-57.|[3]Kumar R, et al. Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine. J Med Chem. 1990 Feb;33 (2) :717-23.