Kisspeptin-54 (human)

Kisspeptin-54 (human) (Metastin (human) ) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54) . Kisspeptin-54 (human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54 (human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[374683-24-6]

Product Name Alternative

Metastin (human)

UNSPSC

12352209

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/kisspeptin-54-human.html

Purity

99.39

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](C)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N7[C@@H](CCC7)C(N[C@@H](C)C(N8[C@@H](CCC8)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N9[C@@H](CCC9)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC%13=CC=CC=C%13)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%14=CC=CC=C%14)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C258H401N79O78

Molecular Weight

5857.43

References & Citations

[1]M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145 (9) :4073-7.|[2]M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276 (37) :34631-6.|[3]Nakamura Y, et al. Metastin stimulates aldosterone synthesis in human adrenal cells. Reprod Sci. 2007 Dec;14 (8) :836-45.|[4]Masui T, et al. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Feb 27;315 (1) :85-92.|[5]Shoji S, et al. Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. European urology, 2009, 55 (2) : 441-451.|[6]Bentsen AH, et al. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides. 2010 Feb;31 (2) :275-83.|[7]Mikkelsen JD, et al. Comparison of the effects of peripherally administered kisspeptins. Regul Pept. 2009 Jan 8;152 (1-3) :95-100.|[8]Matsui H, et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun. 2004 Jul 23;320 (2) :383-8.