Heme Oxygenase-1-IN-1

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1].

Product Specifications

CAS Number

[1093058-52-6]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ho-1-in-1.html

Purity

99.11

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

BrC1=CC=C(CCCCN2C=CN=C2)C=C1

Molecular Formula

C13H15BrN2

Molecular Weight

279.18

References & Citations

[1]Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339.|[2]Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3) -mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1 (HO-1) -NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61.|[3]Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24 (1) :117-132.