Heme Oxygenase-1-IN-1
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1].
Product Specifications
CAS Number
1093058-52-6
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ho-1-in-1.html
Purity
99.11
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(CCCCN2C=CN=C2)C=C1
Molecular Formula
C13H15BrN2
Molecular Weight
279.18
References & Citations
[1]Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339.|[2]Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3) -mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1 (HO-1) -NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61.|[3]Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24 (1) :117-132.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Int Immunopharmacol. 2026 Jan 1;168 (Pt 1) :115795.|J Clin Invest. 2024 Dec 2;134 (23) :e181044.|Mar Drugs. 2025 Mar 12;23 (3) :123.|Arch Oral Biol. 2025 Oct:178:106364.|Cell Death Dis. 2022 Sep 26;13 (9) :822.|Free Radic Biol Med. 2023 Mar 27;202:46-61.|Front Oncol. 2021 May 26:11:679816.|Front Oncol. 2021 Sep 24:11:728047.|J Dent Sci. 2025 Nov 1.|Nitric Oxide. 2022 Dec 1:129:41-52.
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