Human PADI4 Protein, His Tag (active enzyme, MALS verified)
Protein arginine deiminase, type 4 (PADI4) is a calcium dependent enzyme Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. PADI4 can interact with tumor suppressor p53 and regulate the transcriptional activity of p53. Dysregulation of PADI4 is implicated in a variety of diseases, including rheumatoid arthritis, tumor development, and multiple sclerosis.
Product Specifications
UniProt
Q9UM07
Expression Region
Met 1 - Pro 663
Reactivity
Human
Conjugation
Unconjugated
Tag
C-10xHis
Field of Research
Immunology & Inflammation; Epigenetics & Chromatin
Endotoxin
1.0 EU per μg
Purity
90%
Form
Liquid
Molecular Weight
76.0 kDa
Storage Conditions
-70°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.0 kDa. The protein migrates as 70-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
Q9UM07
Preservative
20 mM Tris, 200 mM NaCl, pH 8.0
Available Sizes
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