RYL-552
RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor[1].
Product Specifications
CAS Number
[1801444-56-3]
UNSPSC
12352005
Target
Mitochondrial Metabolism; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ryl-552.html
Concentration
10mM
Purity
98.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C)=C(NC2=C1C(F)=CC=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
Molecular Formula
C24H17F4NO2
Molecular Weight
427.39
References & Citations
[1]Kristin D Lane, et al. Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors. Proc Natl Acad Sci U S A. 2018 Jun 12;115 (24) :6285-6290.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Curated Selection
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