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RYL-552

RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor[1].

Product Specifications

CAS Number

1801444-56-3

UNSPSC

12352005

Target

Mitochondrial Metabolism; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ryl-552.html

Concentration

10mM

Purity

98.63

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C)=C(NC2=C1C(F)=CC=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F

Molecular Formula

C24H17F4NO2

Molecular Weight

427.39

References & Citations

[1]Kristin D Lane, et al. Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors. Proc Natl Acad Sci U S A. 2018 Jun 12;115 (24) :6285-6290.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium

Available Sizes

Frequently Asked Questions

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