Pep2-8

Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1].

Product Specifications

CAS Number

[1541011-97-5]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

PCSK9

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pep2-8.html

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N)=O)C(C)C)[C@@H](NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CO)NC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC(C)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56

Molecular Formula

C83H110N16O24

Molecular Weight

1715.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289 (2) :942-55.