Recombinant Human soluble Receptor Activator of Nuclear Factor kappa-B Receptor/TNFRSF11A
Recombinant Human soluble Receptor Activator of Nuclear Factor kappa-B Receptor/TNFRSF11A
Product Specifications
UniProt
Q9Y6Q6
Source
Escherichia coli
Endotoxin
Less than 0.1 EU/ug of rHusRANK Receptor as determined by LAL method.
Purity
> 98 % by SDS-PAGE and HPLC analyses.
Bioactivity
Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B (NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 x104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Form
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris-HCl, pH 8.0, 150mM NaCl.
Molecular Weight
Approximately 19.1 kDa, a single non-glycosylated polypeptide chain containing 174 amino acids.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Notes
For research use only.
AA Sequence
QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KCTTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVCDTGKAL VAVVAGNSTT PRRCACTAGY HWSQDCECCR RNTECAPGLG AQHPLQLNKD TVCKPCLAGY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK
Available Sizes
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