Pizotifen
Product Specifications
UNSPSC Description
Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pizotifen.html
Purity
98.40
Solubility
DMSO : 20 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4
Molecular Weight
295.44
References & Citations
[1]Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.|[2]Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.|[3]Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23(3-4):376-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0115/Pizotifen-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0115/Pizotifen-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
15574-96-6
Available Sizes
Curated Selection
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