Pizotifen
Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
Product Specifications
CAS Number
[15574-96-6]
Product Name Alternative
Pizotyline; BC-105
UNSPSC
12352005
Hazard Statement
H302, H361
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pizotifen.html
Purity
99.63
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4
Molecular Formula
C19H21NS
Molecular Weight
295.44
Precautions
H302, H361
References & Citations
[1]Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.|[2]Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9 (1) :e87026.|[3]Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23 (3-4) :376-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; α-1 microglobulin
Available Sizes
Curated Selection
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