GNE-900
GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 μM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. Gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity[1].
Product Specifications
CAS Number
[1200126-26-6]
UNSPSC
12352005
Target
Apoptosis; Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-900.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1=NC=C2C(C3=CC(C4=CC=C(CN5CCCCC5)C=C4)=CN=C3N2)=C1
Molecular Formula
C23H21N5
Molecular Weight
367.45
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2
Available Sizes
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