5'-ODMT cEt G Phosphoramidite (Amidite)
Product Specifications
UNSPSC Description
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/5-odmt-cet-g-phosphoramidite-amidite.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C3=C(C(N=C(N3)NC(C(C)C)=O)=O)N=C2)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC
Molecular Weight
881.95
References & Citations
[1]Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.|[2]Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148504/5-ODMT-cEt-G-Phosphoramidite-Amidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148504/5-ODMT-cEt-G-Phosphoramidite-Amidite-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
945628-66-0
Available Sizes
Curated Selection
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