Aureobasidin A

Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity[1][2][3].

Product Specifications

CAS Number

[127785-64-2]

Product Name Alternative

Basifungin

UNSPSC

12352209

Target

Antibiotic; Fungal; Parasite

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aureobasidin-a.html

Purity

99.31

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@](OC1=O)([H])[C@H](C)CC)=O)C)C(C)C)=O)CC2=CC=CC=C2)=O)C)CC3=CC=CC=C3)N(CCC4)[C@]4([H])C(N[C@@](C(N([C@H](C(N[C@H](C(N([C@H]1C(C)(O)C)C)=O)CC(C)C)=O)C(C)C)C)=O)([H])[C@H](C)CC)=O

Molecular Formula

C60H92N8O11

Molecular Weight

1101.42

References & Citations

[1]Zheng L, et al. Chromosome 1 trisomy confers resistance to aureobasidin A in Candida albicans. Front Microbiol. 2023 Mar 17;14:1128160.|[2]Alqaisi AQI, et al. The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis. Parasitology. 2018 Feb;145 (2) :148-155.|[3]Takesako K, et al. Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic. J Antibiot (Tokyo) . 1993 Sep;46 (9) :1414-20.