NSC23925
Product Specifications
UNSPSC Description
NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
Target Antigen
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC23925.html
Purity
99.43
Solubility
DMSO : 14.29 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 4 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
OC(C1NCCCC1)C2=CC(C3=CC=C(OC)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
Molecular Weight
421.36
References & Citations
[1]Yang X, et al. Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis. Int J Cancer. 2015 Oct 15;137(8):2029-39.|[2]Duan Z, et al. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009 Oct 12;4(10):e7415.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19626/NSC23925-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19626/NSC23925-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
858474-14-3
Available Sizes
Curated Selection
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