NSC23925

NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.

Product Specifications

CAS Number

[858474-14-3]

UNSPSC

12352005

Hazard Statement

H301

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC23925.html

Purity

99.43

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 4 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OC(C1NCCCC1)C2=CC(C3=CC=C(OC)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl

Molecular Formula

C22H26Cl2N2O2

Molecular Weight

421.36

Precautions

H301

References & Citations

[1]Yang X, et al. Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis. Int J Cancer. 2015 Oct 15;137 (8) :2029-39.|[2]Duan Z, et al. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009 Oct 12;4 (10) :e7415.