(+) -Sotalol

(+) -Sotalol ((S) -Sotalol) is the S-isomer of Sotalol (HY-103196) . Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+) -Sotalol is an antiarrhythmic agent. (+) -Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

Product Specifications

CAS Number

[30236-32-9]

Product Name Alternative

(S) -Sotalol

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plus-sotalol.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)NC[C@H](C1=CC=C(C=C1)NS(C)(=O)=O)O

Molecular Formula

C12H20N2O3S

Molecular Weight

272.36

References & Citations

[1]ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R) -clorprenaline and (S) -sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727|[2]Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7 (1) :116-25. |[3]Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6 (6) :1132-41.|[4]Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.