Human Matriptase / ST14 Catalytic Domain Protein, His Tag (active enzyme)
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing; Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
Product Specifications
Expression Region
Gly 596 - Val 855
Reactivity
Human
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human Matriptase / ST14 Catalytic Domain Protein, His Tag (orb1786150) is expressed from E. coli cells. It contains AA Gly 596 - Val 855 (Accession # NP_068813) .
Field of Research
Protein Biochemistry
Endotoxin
1.0 EU per μg
Purity
90%
Form
Liquid
Molecular Weight
30.6 kDa
Storage Conditions
-70°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30.6 kDa. The protein migrates as 27-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .
NCBI Accession Number
NP_068813
Preservative
50 mM Tris, 150 mM NaCl, 10 % Trehalose, pH 7.5
Available Sizes
Frequently Asked Questions
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