4-Carboxypyrazole
4-Carboxypyrazole (1H-Pyrazole-4-carboxylic acid) is a metabolite of Fomepizole. 4-Carboxypyrazole is involved in the synthesis of ALKBH1 inhibitors. 4-Carboxypyrazole can be used in the research of gastric cancer[1][2].
Product Specifications
CAS Number
37718-11-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Drug Intermediate; Drug Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-carboxypyrazole.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CNN=C1)O
Molecular Formula
C4H4N2O2
Molecular Weight
112.09
Precautions
H315, H319, H335
References & Citations
[1]McMartin KE, et al. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol (Phila) . 2012 Jun;50 (5) :375-83.|[2]Li F, et al. Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity. J Med Chem. 2024 Sep 12;67 (17) :15456-15475.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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