4-Carboxypyrazole

4-Carboxypyrazole (1H-Pyrazole-4-carboxylic acid) is a metabolite of Fomepizole (HY-B0876) . 4-Carboxypyrazole is involved in the synthesis of ALKBH1 inhibitors. 4-Carboxypyrazole can be used in the research of gastric cancer[1][2].

Product Specifications

CAS Number

[37718-11-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Drug Intermediate; Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-carboxypyrazole.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CNN=C1)O

Molecular Formula

C4H4N2O2

Molecular Weight

112.09

Precautions

H315, H319, H335

References & Citations

[1]McMartin KE, et al. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol (Phila) . 2012 Jun;50 (5) :375-83.|[2]Li F, et al. Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity. J Med Chem. 2024 Sep 12;67 (17) :15456-15475.