LY2940094
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM) . LY2940094 reduces ethanol self-administration in animal models[1].
Product Specifications
CAS Number
1307245-86-8
Product Name Alternative
BTRX-246040
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY-2940094.html
Purity
99.17
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
OCC1=CC=CN=C1N2N=C(C)C(CN3CCC4(C5=C(C=C(Cl)S5)C(F)(F)CO4)CC3)=C2
Molecular Formula
C22H23ClF2N4O2S
Molecular Weight
480.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40 (5) :945-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NOP Receptor/ORL1
Available Sizes
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