LY2940094

LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM) . LY2940094 reduces ethanol self-administration in animal models[1].

Product Specifications

CAS Number

[1307245-86-8]

Product Name Alternative

BTRX-246040

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LY-2940094.html

Purity

99.17

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

OCC1=CC=CN=C1N2N=C(C)C(CN3CCC4(C5=C(C=C(Cl)S5)C(F)(F)CO4)CC3)=C2

Molecular Formula

C22H23ClF2N4O2S

Molecular Weight

480.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40 (5) :945-54.