Naloxone (hydrochloride) (Standard)

Naloxone (hydrochloride) (Standard) is the analytical standard of Naloxone (hydrochloride) . This product is intended for research and analytical applications. Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias[1].

Product Specifications

CAS Number

[357-08-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/naloxone-hydrochloride-standard.html

Purity

99.66

Smiles

OC1=C(O2)C([C@]([C@]2([H])C(CC3)=O)(CCN4CC=C)[C@]3(O)[C@H]4C5)=C5C=C1.Cl

Molecular Formula

C19H22ClNO4

Molecular Weight

363.84

Precautions

H302, H315, H319, H335

References & Citations

[1]McIntosh TK, et al. Beneficial effect of the nonselective opiate antagonist naloxone hydrochloride and the thyrotropin-releasing hormone (TRH) analog YM-14673 on long-term neurobehavioral outcome following experimental brain injury in the rat. J Neurotrau|[2]Izquierdo I, et al. Effect of ACTH, epinephrine, beta-endorphin, naloxone, and of the combination of naloxone or beta-endorphinwith ACTH or epinephrine on memory consolidation. Psychoneuroendocrinology. 1983;8 (1) :81-7.|[3]Soteropoulos GC, et al. Neuromuscular effects of morphine and naloxone. J Pharmacol Exp Ther. 1973 Jan;184 (1) :136-42.|[4]Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21 (5) :804-814.