Z-VAE (OMe) -fmk

Z-VAE (OMe) -fmk is a cell-permeable, irreversible inhibitor of UCHL1 that uniquely binds to the enzyme's P1' site, mimicking the proposed binding mode of an endogenous substrate's C-terminal extension. This compound is a valuable chemical tool for probing UCHL1 function in neurodegenerative disease models and ubiquitin-proteasome system research both in vitro and in vivo.