NOD1-IN-1
NOD1/-IN-1 (Compound 2) is a potent RIPK2 inhibitor with an IC50 value of 0.65 nM determined by ADP-Glo assays. NOD1/-IN-1 selectively inhibits the NOD1 pathway (with an IC50 of 33 nM for NOD1), blocking the production of pro-inflammatory cytokines and thereby reducing inflammation. NOD1/-IN-1 is applicable for research in the field of colitis[1].
Product Specifications
CAS Number
[687627-78-7]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nod1-in-1.html
Smiles
ClC1=CC=C(C=C1O)NC2=NC=NC3=CC(OC)=C(OC)C=C23
Molecular Formula
C16H14ClN3O3
Molecular Weight
331.75
References & Citations
[1]Rivoal M, et al. New Potent RIPK2 Inhibitors as a Promising Therapeutic Avenue for Colitis Through the Blockade of NOD Inflammatory Pathways[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOD1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
