NOD1-IN-1

NOD1/-IN-1 (Compound 2) is a potent RIPK2 inhibitor with an IC50 value of 0.65 nM determined by ADP-Glo assays. NOD1/-IN-1 selectively inhibits the NOD1 pathway (with an IC50 of 33 nM for NOD1), blocking the production of pro-inflammatory cytokines and thereby reducing inflammation. NOD1/-IN-1 is applicable for research in the field of colitis[1].

Product Specifications

CAS Number

[687627-78-7]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nod1-in-1.html

Smiles

ClC1=CC=C(C=C1O)NC2=NC=NC3=CC(OC)=C(OC)C=C23

Molecular Formula

C16H14ClN3O3

Molecular Weight

331.75

References & Citations

[1]Rivoal M, et al. New Potent RIPK2 Inhibitors as a Promising Therapeutic Avenue for Colitis Through the Blockade of NOD Inflammatory Pathways[J]. Journal of Medicinal Chemistry, 2024.