Human TNFα

Tumor necrosis factor alpha (TNF-α), is a member of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation and immune system development. TNF-α is produced by a wide variety of cell types including lymphoid cells. TNFa matures through separation of the extracellular domain from rest of the molecule. It forms a soluble trimer which binds the trimeric TNF receptor (TNFR) . TNF-α is a key cytokine in the development of several inflammatory disorders

Product Specifications

Product Name Alternative

TNFSF1A, TNFSF2

Reactivity

Human, Mouse

Conjugation

Unconjugated

Tag

Histidine

Source

Human

Origin

Recombinant protein expressed as His tage protein in E.coli

Field of Research

Immunology & Inflammation

Concentration

1mg/mL

Dilution

Endotoxin

Not tested

Purity

≥98%

Form

Lyophilized

Solubility

Soluble in PBS at 25°C

Molecular Weight

~26 kDa

Storage Conditions

After reconstitution, store at -20°C; Avoid repeated freeze thaw

Notes

For research use only.

Applications Notes

For research use only

Tested Applications

SDS-PAGE

Host or Source

E. coli

Preservative

No preservative

AA Sequence

MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREESPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL