Irbesartan

Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB) . Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

Product Specifications

CAS Number

[138402-11-6]

Product Name Alternative

SR-47436; BMS-186295

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Irbesartan.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=NC15CCCC5

Molecular Formula

C25H28N6O

Molecular Weight

428.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Schupp M, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation. 2004 May 4;109 (17) :2054-7. Epub 2004 Apr 26.|[2]Ruiz E, et al. Importance of intracellular angiotensin II in vascular smooth muscle cell apoptosis: inhibition by the angiotensin AT1 receptor antagonist irbesartan. Eur J Pharmacol. 2007 Jul 19;567 (3) :231-9. Epub 2007 Apr 6.|[3]Yong Zhong, et al. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. Int Immunopharmacol