Trofinetide acetate

Trofinetide, a synthetic analog of the IGF-1 tripeptide Gly-Pro-Glu, exhibits neuroprotective and anti-inflammatory properties in models of brain injury and neurodegeneration. It has shown efficacy in preclinical studies for conditions including stroke, fragile X syndrome, and Rett syndrome, demonstrating potential in both in vitro neuronal assays and in vivo animal models.