Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GDC-0575 (dihydrochloride)

GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.

Product Specifications

CAS Number

1657014-42-0

Product Name Alternative

ARRY-575 (dihydrochloride) ; RG7741 (dihydrochloride)

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GDC-0575_dihydrochloride.html

Purity

99.32

Solubility

DMSO : 65 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl.[H]Cl

Molecular Formula

C16H22BrCl2N5O

Molecular Weight

451.19

References & Citations

[1]Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8 (1) :1679.|[2]Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Jun 15;24 (12) :2901-2912.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Chk1

Citation 01

BioRxiv. 2023 Feb 7.|Mol Cancer Res. 2020 Jan;18 (1) :91-104.|Mol Cancer. 2024 Apr 29;23 (1) :86.|Nat Commun. 2020 Jan 8;11 (1) :123. |Neurotherapeutics. 2022 Mar;19 (2) :570-591.|Research Square Preprint. 2024 Nov 06.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Trib2 Mouse Gene Knockout Kit (CRISPR)
KN518177 1 Kit

Trib2 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Cytokeratin 8 (KRT8) (KRT8/2174R), 0.2mg/mL
BNUB2174-100 1x 100 µL

Cytokeratin 8 (KRT8) (KRT8/2174R), 0.2mg/mL

Sign In for Pricing
View Details
N,N′-Disuccinimidyl Carbonate
TRC-D493540-5G 5 g

N,N′-Disuccinimidyl Carbonate

Sign In for Pricing
View Details
HLA Class II DRB1 Recombinant Rabbit Monoclonal Antibody [JE60-43]
HA721927 100 µL

HLA Class II DRB1 Recombinant Rabbit Monoclonal Antibody [JE60-43]

Sign In for Pricing
View Details
3-(2-(Diisopropylamino)ethyl)-1H-indol-4-ol
TRC-D282513-750MG 750 mg

3-(2-(Diisopropylamino)ethyl)-1H-indol-4-ol

Sign In for Pricing
View Details
p60 CAF1 (CHAF1B) (NM_005441) Human Over-expression Lysate
LY401669 100 µg

p60 CAF1 (CHAF1B) (NM_005441) Human Over-expression Lysate

Sign In for Pricing
View Details