GDC-0575 (dihydrochloride)
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
Product Specifications
CAS Number
1657014-42-0
Product Name Alternative
ARRY-575 (dihydrochloride) ; RG7741 (dihydrochloride)
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GDC-0575_dihydrochloride.html
Purity
99.32
Solubility
DMSO : 65 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl.[H]Cl
Molecular Formula
C16H22BrCl2N5O
Molecular Weight
451.19
References & Citations
[1]Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8 (1) :1679.|[2]Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Jun 15;24 (12) :2901-2912.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Chk1
Citation 01
BioRxiv. 2023 Feb 7.|Mol Cancer Res. 2020 Jan;18 (1) :91-104.|Mol Cancer. 2024 Apr 29;23 (1) :86.|Nat Commun. 2020 Jan 8;11 (1) :123. |Neurotherapeutics. 2022 Mar;19 (2) :570-591.|Research Square Preprint. 2024 Nov 06.
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