JNJ-5207852
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
Product Specifications
CAS Number
398473-34-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/JNJ-5207852.html
Purity
98.0
Solubility
DMSO : 77.5 mg/mL (ultrasonic)
Smiles
N1(CCCOC2=CC=C(CN3CCCCC3)C=C2)CCCCC1
Molecular Formula
C20H32N2O
Molecular Weight
316.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143 (5) :649-61.|[2]Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
Available Sizes
Frequently Asked Questions
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