JNJ-5207852

JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

Product Specifications

CAS Number

[398473-34-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/JNJ-5207852.html

Purity

98.0

Solubility

DMSO : 77.5 mg/mL (ultrasonic)

Smiles

N1(CCCOC2=CC=C(CN3CCCCC3)C=C2)CCCCC1

Molecular Formula

C20H32N2O

Molecular Weight

316.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143 (5) :649-61.|[2]Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.