NMS-859
NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
Product Specifications
CAS Number
[1449236-96-7]
UNSPSC
12352005
Hazard Statement
H302, H314
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NMS-859.html
Purity
98.05
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S1(C2=CC=CC=C2C(NC3=CC(NC(CCl)=O)=CC=C3)=N1)=O
Molecular Formula
C15H12ClN3O3S
Molecular Weight
349.79
Precautions
H302, H314
References & Citations
[1]Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9 (9) :548-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
M2423-11 10 µg
Matrix Metalloproteinase 7, Pro, Recombinant (ProMMP-7, Promatrilysin) discontinued
Ask
View Details