Cdk5 Substrate

This synthetic peptide (PKTPKKAKKL), derived from histone H1, serves as a specific substrate for cyclin-dependent kinase 5 (Cdk5), exhibiting a Km of 5 μM. It is a valuable tool for in vitro kinase assays to study Cdk5/p35 activity, which is implicated in neuronal signaling and tau phosphorylation pathways.