TAME
TAME is a cell-permeable inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C) . It functions by competitively blocking the binding of the activators Cdc20 and Cdh1, thereby inhibiting APC/C-dependent proteolysis. This compound is a valuable tool for studying cell cycle regulation, mitotic exit, and aneuploidy in both cellular and biochemical assays.
Product Specifications
Product Name Alternative
Tosyl-Arginine Methyl Este, Tosylarginine methyl ester, TAME, APC, Anaphase promoting complex, N-4-Tosyl-L-arginine methyl ester
Field of Research
Cell Biology
Solubility
Ethanol:3 mg/mL (8.76 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.64 mM) ; H2O:63 mg/mL (183.99 mM) ; DMSO:80 mg/mL (233.64 mM)
Molecular Weight
342.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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