H-Dab (Boc) -OH

H-Dab (Boc) -OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities[1].

Product Specifications

CAS Number

[10270-94-7]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/h-dab-boc-oh.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C([C@H](CCNC(OC(C)(C)C)=O)N)O

Molecular Formula

C9H18N2O4

Molecular Weight

218.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Rosowsky, et al. "Methotrexate analogs. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogs containing a basic amino acid side chain." Journal of medicinal chemistry 29.5 (1986) : 655-660.