CLK1/2-IN-1
CLK1/2-IN-2 is CLK1 and CLK2 inhibitor with IC50 values of 16 nM and 45 nM, respectively. CLK1/2-IN-2 exhibits potent anti-cancer activities[1].
Product Specifications
CAS Number
[1005784-23-5]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clk1-2-in-1.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(NC1=CN2C=C(C(F)(F)F)C=CC2=N1)C3=CC=C(C(C)(C)CCC4=NNN=N4)C=C3
Molecular Formula
C21H20F3N7O
Molecular Weight
443.43
References & Citations
[1]Shinsuke Araki, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
Available Sizes
Curated Selection
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