G-Protein antagonist peptide

This peptide, derived from Substance P, acts as a competitive and reversible inhibitor of G protein coupling to specific receptors. It blocks M2 muscarinic receptor-mediated activation of Gi/Go proteins and inhibits Gs activation by β-adrenoceptors. This tool is valuable for in vitro studies of G protein-coupled receptor (GPCR) signaling and cellular transduction pathways.